Traveling can be great fun but again be well prepared. Know your stuff, know who to trust and follow the news.
In some places the bus is very good, like a decent transportation way but it’s not safe. Last time there was an accident up in the hills of South America where people got killed. Those busess will never get any maintenance, and therefor if you follow the news you get a sense of what is good and what is bad.
In the general rule, traveling by plane is often still safe. This is because the product is so expensive they will think twice before crashing it. Unless the plane is very old and the country you are residing in has his issues.